The multi-site docking protein Grb2-associated binder 1 (Gab1) enhances interleukin-6-induced MAPK-pathway activation in an SHP2-, Grb2-, and time-dependent manner

BACKGROUND: Cytokine-dependent activation of signalling pathways is tightly orchestrated. The spatiotemporal activation of signalling pathways dictates the specific physiological responses to cytokines. Dysregulated signalling accounts for neoplastic, developmental, and inflammatory diseases. Grb2-a...

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Vydáno v:Cell Commun Signal
Hlavní autoři: Bongartz, Hannes, Gille, Karen, Hessenkemper, Wiebke, Mandel, Katharina, Lewitzky, Marc, Feller, Stephan M., Schaper, Fred
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2019
Témata:
Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6814103/
https://ncbi.nlm.nih.gov/pubmed/31651330
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12964-019-0451-2
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