The Mithralog EC-7072 Induces Chronic Lymphocytic Leukemia Cell Death by Targeting Tonic B-Cell Receptor Signaling

B-cell receptor (BCR)-dependent signaling is central for leukemia B-cell homeostasis, as underscored by the promising clinical results obtained in patients with chronic lymphocytic leukemia (CLL) treated with novel agents targeting components of this pathway. Herein, we demonstrate that the mithralo...

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Bibliographische Detailangaben
Veröffentlicht in:Front Immunol
Hauptverfasser: Lorenzo-Herrero, Seila, Sordo-Bahamonde, Christian, Bretones, Gabriel, Payer, Ángel R., González-Rodríguez, Ana P., González-García, Esther, Pérez-Escuredo, Jhudit, Villa-Álvarez, Mónica, Núñez, Luz-Elena, Morís, Francisco, Gonzalez, Segundo, López-Soto, Alejandro
Format: Artigo
Sprache:Inglês
Veröffentlicht: Frontiers Media S.A. 2019
Schlagworte:
Immunology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6813538/
https://ncbi.nlm.nih.gov/pubmed/31681329
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2019.02455
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