Pleiotropic Anti-Angiogenic and Anti-Oncogenic Activities of the Novel Mithralog Demycarosyl-3D-ß-D-Digitoxosyl-Mithramycin SK (EC-8042)

Demycarosyl-3D-ß-D-digitoxosyl-mithramycin SK (DIG-MSK) is a recently isolated analogue of mithramycin A (MTA) that showed differences with MTA in the DNA binding strength and selectivity. These differences correlated with a better therapeutic index and less toxicity in animal studies. Herein, we sh...

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Udgivet i:PLoS One
Main Authors: Fernández-Guizán, Azahara, López-Soto, Alejandro, Acebes-Huerta, Andrea, Huergo-Zapico, Leticia, Villa-Álvarez, Mónica, Núñez, Luz-Elena, Morís, Francisco, Gonzalez, Segundo
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2015
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4633274/
https://ncbi.nlm.nih.gov/pubmed/26536461
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0140786
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