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A nucleotide resolution map of Top2-linked DNA breaks in the yeast and human genome
DNA topoisomerases are required to resolve DNA topological stress. Despite this essential role, abortive topoisomerase activity generates aberrant protein-linked DNA breaks, jeopardising genome stability. Here, to understand the genomic distribution and mechanisms underpinning topoisomerase-induced...
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| Pubblicato in: | Nat Commun |
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| Autori principali: | , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Nature Publishing Group UK
2019
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6813358/ https://ncbi.nlm.nih.gov/pubmed/31649282 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-12802-5 |
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