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Inhibiting microRNA-144 potentiates Nrf2-dependent antioxidant signaling in RPE and protects against oxidative stress-induced outer retinal degeneration

The retinal pigment epithelium (RPE) is consistently exposed to high levels of pro-oxidant and inflammatory stimuli. As such, under normal conditions the antioxidant machinery in the RPE cell is one of the most efficient in the entire body. However, antioxidant defense mechanisms are often impacted...

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Vydáno v:Redox Biol
Hlavní autoři: Jadeja, Ravirajsinh N., Jones, Malita A., Abdelrahman, Ammar A., Powell, Folami L., Thounaojam, Menaka C., Gutsaeva, Diana, Bartoli, Manuela, Martin, Pamela M.
Médium: Artigo
Jazyk:Inglês
Vydáno: Elsevier 2019
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6812120/
https://ncbi.nlm.nih.gov/pubmed/31590045
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.redox.2019.101336
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