An exploratory randomized-controlled trial of the efficacy of the Src-kinase inhibitor saracatinib as a novel analgesic for cancer-induced bone pain

Pain is a major symptom of bone metastases from advanced cancer and represents a clinical challenge to treat effectively. Basic neurobiology in preclinical animal models implicates enhanced sensory processing in the central nervous system, acting through N-methyl-D-aspartate (NMDA) glutamate recepto...

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Vydáno v:J Bone Oncol
Hlavní autoři: Danson, Sarah, Mulvey, Matthew R, Turner, Lesley, Horsman, Janet, Escott, KJane, Coleman, Robert E, Ahmedzai, Sam H, Bennett, Michael I, Andrew, David
Médium: Artigo
Jazyk:Inglês
Vydáno: Elsevier 2019
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6812043/
https://ncbi.nlm.nih.gov/pubmed/31667062
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jbo.2019.100261
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