In Vitro Activity of Ibrexafungerp, a Novel Glucan Synthase Inhibitor against Candida glabrata Isolates with FKS Mutations

Ibrexafungerp is a first-in-class glucan synthase inhibitor. In vitro activity was determined for 89 Candida glabrata isolates with molecularly identified FKS1 or FKS2 mutations conferring resistance to the echinocandins. All isolates were resistant to at least one echinocandin (i.e., anidulafungin,...

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Udgivet i:Antimicrob Agents Chemother
Main Authors: Nunnally, Natalie S., Etienne, Kizee A., Angulo, David, Lockhart, Shawn R., Berkow, Elizabeth L.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2019
Fag:
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Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6811432/
https://ncbi.nlm.nih.gov/pubmed/31481447
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01692-19
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