Determination of Pharmacodynamic Target Exposures for Rezafungin against Candida tropicalis and Candida dubliniensis in the Neutropenic Mouse Disseminated Candidiasis Model

Rezafungin (CD101) is a novel echinocandin under development for once-weekly intravenous (i.v.) dosing. We evaluated the pharmacodynamics (PD) of rezafungin against 4 Candida tropicalis and 4 Candida dubliniensis strains, using the neutropenic mouse invasive candidiasis model. The area under the con...

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Bibliographic Details
Published in:Antimicrob Agents Chemother
Main Authors: Lepak, Alexander J., Zhao, Miao, Andes, David R.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2019
Subjects:
Experimental Therapeutics
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6811416/
https://ncbi.nlm.nih.gov/pubmed/31481440
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01556-19
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