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Isocitrate dehydrogenase inhibitors in acute myeloid leukemia
Isocitrate dehydrogenase (IDH) is a key enzyme involved in the conversion of isocitrate to α-ketoglutarate (α-KG) in the tricarboxylic acid (TCA) cycle. IDH mutation produces a neomorphic enzyme, which can lead to the abnormal accumulation of R-2-HG and promotes leukemogenesis. IDH mutation occurs i...
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| 出版年: | Biomark Res |
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| 主要な著者: | , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
BioMed Central
2019
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6806510/ https://ncbi.nlm.nih.gov/pubmed/31660152 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40364-019-0173-z |
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