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Isocitrate dehydrogenase inhibitors in acute myeloid leukemia
Isocitrate dehydrogenase (IDH) is a key enzyme involved in the conversion of isocitrate to α-ketoglutarate (α-KG) in the tricarboxylic acid (TCA) cycle. IDH mutation produces a neomorphic enzyme, which can lead to the abnormal accumulation of R-2-HG and promotes leukemogenesis. IDH mutation occurs i...
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| Publicado no: | Biomark Res |
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| Main Authors: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
BioMed Central
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6806510/ https://ncbi.nlm.nih.gov/pubmed/31660152 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40364-019-0173-z |
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