The mTOR kinase inhibitor rapamycin enhances the expression and release of pro-inflammatory cytokine interleukin 6 modulating the activation of human microglial cells

Emerging evidence suggests the potential use of rapamycin in treatment of several neurological disorders. The drug readily crosses the blood brain barrier and may exert direct immunomodulatory effects within the brain. Microglia are the main innate immune cells of the brain, thus critically involved...

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Publicat a:EXCLI J
Autors principals: Cappoli, Natalia, Mezzogori, Daniele, Tabolacci, Elisabetta, Coletta, Isabella, Navarra, Pierluigi, Pani, Giovambattista, Dello Russo, Cinzia
Format: Artigo
Idioma:Inglês
Publicat: Leibniz Research Centre for Working Environment and Human Factors 2019
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Original Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6806201/
https://ncbi.nlm.nih.gov/pubmed/31645839
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.17179/excli2019-1715
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