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Local Investigators Significantly Overestimate Overall Response Rates Compared to Blinded Independent Central Reviews in Uncontrolled Oncology Trials: A Comprehensive Review of the Literature

Several drugs gained market authorization based on the demonstration of improved progression-free survival (PFS), adopted as a primary endpoint in Phase 3 clinical trials. In addition, an increasing number of drugs have been granted accelerated approval, and sometimes regular approval, by the main r...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
मुख्य लेखकों: Cinzia Dello Russo, Pierluigi Navarra
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: Frontiers Media S.A. 2022-05-01
श्रृंखला:Frontiers in Pharmacology
विषय:
ORR
PFS
ऑनलाइन पहुंच:https://www.frontiersin.org/articles/10.3389/fphar.2022.858354/full
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