MLH1 deficiency leads to deregulated mitochondrial metabolism

The DNA mismatch repair (MMR) pathway is responsible for the repair of base–base mismatches and insertion/deletion loops that arise during DNA replication. MMR deficiency is currently estimated to be present in 15–17% of colorectal cancer cases and 30% of endometrial cancers. MLH1 is one of the key...

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Detalhes bibliográficos
Publicado no:Cell Death Dis
Main Authors: Rashid, Sukaina, Freitas, Marta O., Cucchi, Danilo, Bridge, Gemma, Yao, Zhi, Gay, Laura, Williams, Marc, Wang, Jun, Suraweera, Nirosha, Silver, Andrew, McDonald, Stuart A. C., Chelala, Claude, Szabadkai, Gyorgy, Martin, Sarah A.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6805956/
https://ncbi.nlm.nih.gov/pubmed/31641109
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-019-2018-y
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