Mitochondrial Dysfunction, Through Impaired Autophagy, Leads to Endoplasmic Reticulum Stress, Deregulated Lipid Metabolism, and Pancreatitis in Animal Models

BACKGROUND & AIMS: Little is known about the signaling pathways that initiate and promote acute pancreatitis (AP). The pathogenesis of AP has been associated with abnormal increases in cytosolic Ca(2+), mitochondrial dysfunction, impaired autophagy, and endoplasmic reticulum (ER) stress. We anal...

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Publicado no:Gastroenterology
Principais autores: Biczo, Gyorgy, Vegh, Eszter T., Shalbueva, Natalia, Mareninova, Olga A., Elperin, Jason, Lotshaw, Ethan, Gretler, Sophie, Lugea, Aurelia, Malla, Sudarshan R., Dawson, David, Ruchala, Piotr, Whitelegge, Julian, French, Samuel W., Wen, Li, Husain, Sohail Z., Gorelick, Fred S., Hegyi, Peter, Rakonczay, Zoltan, Gukovsky, Ilya, Gukovskaya, Anna S.
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6369139/
https://ncbi.nlm.nih.gov/pubmed/29074451
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1053/j.gastro.2017.10.012
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