Preclinical Proof-of-Concept, Analytical Development, and Commercial Scale Production of Lentiviral Vector in Adherent Cells

The therapeutic efficacy of a lentiviral vector (LV) expressing the herpes simplex virus thymidine kinase (HSV-TK) was studied in an immunocompetent rat glioblastoma model. Intraperitoneal ganciclovir injections (50 mg/kg/day) were administered for 14 consecutive days, resulting in reduced tumor vol...

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Pubblicato in:Mol Ther Methods Clin Dev
Autori principali: Leinonen, Hanna M., Lipponen, Eevi M., Valkama, Anniina J., Hynynen, Heidi, Oruetxebarria, Igor, Turkki, Vesa, Olsson, Venla, Kurkipuro, Jere, Samaranayake, Haritha, Määttä, Ann-Marie, Parker, Nigel R., Ylä-Herttuala, Seppo, Lesch, Hanna P.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society of Gene & Cell Therapy 2019
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6804948/
https://ncbi.nlm.nih.gov/pubmed/31649956
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.omtm.2019.08.006
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