Lentiviral Protein Transduction with Genome-Modifying HIV-1 Integrase-I-PpoI Fusion Proteins: Studies on Specificity and Cytotoxicity

Rare-cutting endonucleases, such as the I-PpoI, can be used for the induction of double strand breaks (DSBs) in genome editing and targeted integration based on homologous recombination. For therapeutic approaches, the specificity and the pattern of off-target effects are of high importance in these...

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Bibliografski detalji
Glavni autori: Turkki, Vesa, Schenkwein, Diana, Timonen, Oskari, Husso, Tiia, Lesch, Hanna P., Ylä-Herttuala, Seppo
Format: Artigo
Jezik:Inglês
Izdano: Hindawi Publishing Corporation 2014
Teme:
Research Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4016911/
https://ncbi.nlm.nih.gov/pubmed/24860818
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2014/379340
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