Development of Large-Scale Downstream Processing for Lentiviral Vectors

The interest in lentiviral vectors (LVs) has increased prominently for gene therapy applications, but few have reached the later stages of clinical trials. The main challenge has remained in scaling up the manufacturing process for the fragile vector to obtain high titers for in vivo usage. We have...

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Udgivet i:Mol Ther Methods Clin Dev
Main Authors: Valkama, Anniina J., Oruetxebarria, Igor, Lipponen, Eevi M., Leinonen, Hanna M., Käyhty, Piia, Hynynen, Heidi, Turkki, Vesa, Malinen, Joonas, Miinalainen, Tuukka, Heikura, Tommi, Parker, Nigel R., Ylä-Herttuala, Seppo, Lesch, Hanna P.
Format: Artigo
Sprog:Inglês
Udgivet: American Society of Gene & Cell Therapy 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7177191/
https://ncbi.nlm.nih.gov/pubmed/32346549
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.omtm.2020.03.025
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