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Optimization of lentiviral vector production for scale-up in fixed-bed bioreactor

Lentiviral vectors (LVs) are promising tools for gene therapy. However, scaling up the production methods of LVs in order to produce high-quality vectors for clinical purposes has proven to be difficult. In this article, we present a scalable and efficient method to produce LVs with transient transf...

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Detalhes bibliográficos
Publicado no:Gene Ther
Main Authors: Valkama, A J, Leinonen, H M, Lipponen, E M, Turkki, V, Malinen, J, Heikura, T, Ylä-Herttuala, S, Lesch, H P
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5817386/
https://ncbi.nlm.nih.gov/pubmed/29345252
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/gt.2017.91
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