Double-Hit Gene Expression Signature Defines a Distinct Subgroup of Germinal Center B-Cell-Like Diffuse Large B-Cell Lymphoma

PURPOSE: High-grade B-cell lymphoma with MYC and BCL2 and/or BCL6 rearrangements (HGBL-DH/TH) has a poor outcome after standard chemoimmunotherapy. We sought to understand the biologic underpinnings of HGBL-DH/TH with BCL2 rearrangements (HGBL-DH/TH-BCL2) and diffuse large B-cell lymphoma (DLBCL) mo...

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Pubblicato in:J Clin Oncol
Autori principali: Ennishi, Daisuke, Jiang, Aixiang, Boyle, Merrill, Collinge, Brett, Grande, Bruno M., Ben-Neriah, Susana, Rushton, Christopher, Tang, Jeffrey, Thomas, Nicole, Slack, Graham W., Farinha, Pedro, Takata, Katsuyoshi, Miyata-Takata, Tomoko, Craig, Jeffrey, Mottok, Anja, Meissner, Barbara, Saberi, Saeed, Bashashati, Ali, Villa, Diego, Savage, Kerry J., Sehn, Laurie H., Kridel, Robert, Mungall, Andrew J., Marra, Marco A., Shah, Sohrab P., Steidl, Christian, Connors, Joseph M., Gascoyne, Randy D., Morin, Ryan D., Scott, David W.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society of Clinical Oncology 2019
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RAPID COMMUNICATIONS
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6804880/
https://ncbi.nlm.nih.gov/pubmed/30523716
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1200/JCO.18.01583
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