Double-Hit Gene Expression Signature Defines a Distinct Subgroup of Germinal Center B-Cell-Like Diffuse Large B-Cell Lymphoma

PURPOSE: High-grade B-cell lymphoma with MYC and BCL2 and/or BCL6 rearrangements (HGBL-DH/TH) has a poor outcome after standard chemoimmunotherapy. We sought to understand the biologic underpinnings of HGBL-DH/TH with BCL2 rearrangements (HGBL-DH/TH-BCL2) and diffuse large B-cell lymphoma (DLBCL) mo...

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Published in:J Clin Oncol
Main Authors: Ennishi, Daisuke, Jiang, Aixiang, Boyle, Merrill, Collinge, Brett, Grande, Bruno M., Ben-Neriah, Susana, Rushton, Christopher, Tang, Jeffrey, Thomas, Nicole, Slack, Graham W., Farinha, Pedro, Takata, Katsuyoshi, Miyata-Takata, Tomoko, Craig, Jeffrey, Mottok, Anja, Meissner, Barbara, Saberi, Saeed, Bashashati, Ali, Villa, Diego, Savage, Kerry J., Sehn, Laurie H., Kridel, Robert, Mungall, Andrew J., Marra, Marco A., Shah, Sohrab P., Steidl, Christian, Connors, Joseph M., Gascoyne, Randy D., Morin, Ryan D., Scott, David W.
Format: Artigo
Language:Inglês
Published: American Society of Clinical Oncology 2019
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6804880/
https://ncbi.nlm.nih.gov/pubmed/30523716
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1200/JCO.18.01583
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