Computationally Guided Design of Single-Chain Variable Fragment Improves Specificity of Chimeric Antigen Receptors

Chimeric antigen receptor (CAR)-T cell-based immunotherapy of malignant disease relies on the specificity and association constant of single-chain variable fragments (scFvs). The latter are synthesized from parent antibodies by fusing their light (V(L)) and heavy (V(H))-chain variable domains into a...

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Publicat a:Mol Ther Oncolytics
Autors principals: Krokhotin, Andrey, Du, Hongwei, Hirabayashi, Koichi, Popov, Konstantin, Kurokawa, Tomohiro, Wan, Xinhui, Ferrone, Soldano, Dotti, Gianpietro, Dokholyan, Nikolay V.
Format: Artigo
Idioma:Inglês
Publicat: American Society of Gene & Cell Therapy 2019
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6804740/
https://ncbi.nlm.nih.gov/pubmed/31650023
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.omto.2019.08.008
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