Antitumor Responses in the Absence of Toxicity in Solid Tumors by Targeting B7-H3 via Chimeric Antigen Receptor T Cells

The high expression across multiple tumor types and restricted expression in normal tissues make B7-H3 an attractive target for immunotherapy. We generated chimeric antigen receptor (CAR) T cells targeting B7-H3 (B7-H3.CAR-Ts) and found that B7-H3.CAR-Ts controlled the growth of pancreatic ductal ad...

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Gepubliceerd in:Cancer Cell
Hoofdauteurs: Du, Hongwei, Hirabayashi, Koichi, Ahn, Sarah, Kren, Nancy Porterfield, Montgomery, Stephanie Ann, Wang, Xinhui, Tiruthani, Karthik, Mirlekar, Bhalchandra, Michaud, Daniel, Greene, Kevin, Herrera, Silvia Gabriela, Xu, Yang, Sun, Chuang, Chen, Yuhui, Ma, Xingcong, Ferrone, Cristina Rosa, Pylayeva-Gupta, Yuliya, Yeh, Jen Jen, Liu, Rihe, Savoldo, Barbara, Ferrone, Soldano, Dotti, Gianpietro
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2019
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6645919/
https://ncbi.nlm.nih.gov/pubmed/30753824
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccell.2019.01.002
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