Crucial Role of the SH2B1 PH Domain for the Control of Energy Balance

Disruption of the adaptor protein SH2B1 (SH2-B, PSM) is associated with severe obesity, insulin resistance, and neurobehavioral abnormalities in mice and humans. Here, we identify 15 SH2B1 variants in severely obese children. Four obesity-associated human SH2B1 variants lie in the Pleckstrin homolog...

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Detalhes bibliográficos
Publicado no:Diabetes
Main Authors: Flores, Anabel, Argetsinger, Lawrence S., Stadler, Lukas K.J., Malaga, Alvaro E., Vander, Paul B., DeSantis, Lauren C., Joe, Ray M., Cline, Joel M., Keogh, Julia M., Henning, Elana, Barroso, Ines, Mendes de Oliveira, Edson, Chandrashekar, Gowri, Clutter, Erik S., Hu, Yixin, Stuckey, Jeanne, Farooqi, I. Sadaf, Myers, Martin G., Carter-Su, Christin
Formato: Artigo
Idioma:Inglês
Publicado em: American Diabetes Association 2019
Assuntos:
Obesity Studies
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6804625/
https://ncbi.nlm.nih.gov/pubmed/31439647
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db19-0608
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