Human SH2B1 mutations are associated with maladaptive behaviors and obesity

Src homology 2 B adapter protein 1 (SH2B1) modulates signaling by a variety of ligands that bind to receptor tyrosine kinases or JAK-associated cytokine receptors, including leptin, insulin, growth hormone (GH), and nerve growth factor (NGF). Targeted deletion of Sh2b1 in mice results in increased f...

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Detalhes bibliográficos
Main Authors: Doche, Michael E., Bochukova, Elena G., Su, Hsiao-Wen, Pearce, Laura R., Keogh, Julia M., Henning, Elana, Cline, Joel M., Dale, Anne, Cheetham, Tim, Barroso, Inês, Argetsinger, Lawrence S., O’Rahilly, Stephen, Rui, Liangyou, Carter-Su, Christin, Farooqi, I. Sadaf
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2012
Assuntos:
Brief Report
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3533535/
https://ncbi.nlm.nih.gov/pubmed/23160192
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI62696
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