Deletion of the Brain-Specific α and δ Isoforms of Adapter Protein SH2B1 Protects Mice From Obesity

Mice lacking SH2B1 and humans with variants of SH2B1 display severe obesity and insulin resistance. SH2B1 is an adapter protein that is recruited to the receptors of multiple hormones and neurotrophic factors. Of the four known alternatively spliced SH2B1 isoforms, SH2B1β and SH2B1γ exhibit ubiquito...

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Veröffentlicht in:Diabetes
Hauptverfasser: Cote, Jessica L., Argetsinger, Lawrence S., Flores, Anabel, Rupp, Alan C., Cline, Joel M., DeSantis, Lauren C., Bedard, Alexander H., Bagchi, Devika P., Vander, Paul B., Cacciaglia, Abrielle M., Clutter, Erik S., Chandrashekar, Gowri, MacDougald, Ormond A., Myers, Martin G., Carter-Su, Christin
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Diabetes Association 2021
Schlagworte:
Obesity Studies
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7881872/
https://ncbi.nlm.nih.gov/pubmed/33214137
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db20-0687
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