Phosphorylation of the Unique C-Terminal Tail of the Alpha Isoform of the Scaffold Protein SH2B1 Controls the Ability of SH2B1α To Enhance Nerve Growth Factor Function

The scaffold protein SH2B1, a major regulator of body weight, is recruited to the receptors of multiple cytokines and growth factors, including nerve growth factor (NGF). The β isoform but not the α isoform of SH2B1 greatly enhances NGF-dependent neurite outgrowth of PC12 cells. Here, we asked how t...

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Detalhes bibliográficos
Publicado no:Mol Cell Biol
Main Authors: Joe, Ray M., Flores, Anabel, Doche, Michael E., Cline, Joel M., Clutter, Erik S., Vander, Paul B., Riedel, Heimo, Argetsinger, Lawrence S., Carter-Su, Christin
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2018
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5829484/
https://ncbi.nlm.nih.gov/pubmed/29229648
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00277-17
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