Design, Synthesis and Biological Evaluation of Pentacyclic Triterpene Derivatives: Optimization of Anti-ABL Kinase Activity

Imatinib, an Abelson (ABL) tyrosine kinase inhibitor, is a lead molecular-targeted drug against chronic myelogenous leukemia (CML). To overcome its resistance and adverse effects, new inhibitors of ABL kinase are needed. Our previous study showed that the benzyl ester of gypsogenin (1c), a pentacycl...

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Vydáno v:Molecules
Hlavní autoři: I. Ciftci, Halil, O. Radwan, Mohamed, E. Ozturk, Safiye, Ulusoy, N. Gokce, Sozer, Ece, E. Ellakwa, Doha, Ocak, Zeynep, Can, Mustafa, F.S. Ali, Taha, I. Abd-Alla, Howaida, Yayli, Nurettin, Tateishi, Hiroshi, Otsuka, Masami, Fujita, Mikako
Médium: Artigo
Jazyk:Inglês
Vydáno: MDPI 2019
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6804044/
https://ncbi.nlm.nih.gov/pubmed/31574910
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules24193535
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