Design, Synthesis and Biological Evaluation of Pentacyclic Triterpene Derivatives: Optimization of Anti-ABL Kinase Activity

Imatinib, an Abelson (ABL) tyrosine kinase inhibitor, is a lead molecular-targeted drug against chronic myelogenous leukemia (CML). To overcome its resistance and adverse effects, new inhibitors of ABL kinase are needed. Our previous study showed that the benzyl ester of gypsogenin (1c), a pentacycl...

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Publicat a:Molecules
Autors principals: I. Ciftci, Halil, O. Radwan, Mohamed, E. Ozturk, Safiye, Ulusoy, N. Gokce, Sozer, Ece, E. Ellakwa, Doha, Ocak, Zeynep, Can, Mustafa, F.S. Ali, Taha, I. Abd-Alla, Howaida, Yayli, Nurettin, Tateishi, Hiroshi, Otsuka, Masami, Fujita, Mikako
Format: Artigo
Idioma:Inglês
Publicat: MDPI 2019
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6804044/
https://ncbi.nlm.nih.gov/pubmed/31574910
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules24193535
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