A CRISPR Screen Identifies the Cell Polarity Determinant Crumbs 3 as an Adeno-associated Virus Restriction Factor in Hepatocytes

Adeno-associated viruses (AAV) are helper-dependent parvoviruses that have been developed into promising gene therapy vectors. Many studies, including a recent unbiased genomic screen, have identified host factors essential for AAV cell entry, but no genome-wide screens that address inhibitory host...

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Bibliografske podrobnosti
izdano v:J Virol
Main Authors: Madigan, Victoria J., Tyson, Tyne O., Yuziuk, Julianne A., Pillai, Minakshi, Moller-Tank, Sven, Asokan, Aravind
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 2019
Teme:
Virus-Cell Interactions
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6803288/
https://ncbi.nlm.nih.gov/pubmed/31391273
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00943-19
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