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Strategies to circumvent humoral immunity to adeno-associated viral vectors

INTRODUCTION: Recent success in gene therapy of certain monogenic diseases in the clinic has infused enthusiasm into the continued development of recombinant adeno-associated viral (AAV) vectors as next-generation biologics. However, progress in clinical trials has also highlighted the challenges po...

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Enregistré dans:
Détails bibliographiques
Publié dans:Expert Opin Biol Ther
Auteurs principaux: Tse, Longping V, Moller-Tank, Sven, Asokan, Aravind
Format: Artigo
Langue:Inglês
Publié: 2015
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4689135/
https://ncbi.nlm.nih.gov/pubmed/25985812
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1517/14712598.2015.1035645
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