High levels of Daxx due to low cellular levels of HSP25 in murine cancer cells result in inefficient adenovirus replication

When the adenoviral protein E1B55K binds death domain-associated protein (Daxx), the proteasome-dependent degradation of Daxx is initiated, and adenoviral replication is effectively maintained. Here, we show that the cellular levels of Daxx differ between human and mouse cancer cell lines. Specifica...

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Gepubliceerd in:Exp Mol Med
Hoofdauteurs: Han, Zhezhu, Joo, Yeonsoo, Lee, Jihyun, Ko, Suwan, Xu, Rong, Oh, Geun-Hyeok, Choi, Soojin, Hong, Jeong A., Choi, Hye Jin, Song, Jae J.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Nature Publishing Group UK 2019
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6802665/
https://ncbi.nlm.nih.gov/pubmed/31615977
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s12276-019-0321-4
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