Adenovirus E1B 55-Kilodalton Oncoprotein Binds to Daxx and Eliminates Enhancement of p53-Dependent Transcription by Daxx

The adenovirus E1B 55-kDa protein impairs the p53 pathway and enhances transformation, although the underlying mechanisms remain to be defined. We found that Daxx binds to the E1B 55-kDa protein in a yeast two-hybrid screen. The two proteins interact through their C termini. Mutation of three potent...

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Bibliografiske detaljer
Main Authors: Zhao, Lisa Y., Colosimo, April L., Liu, Yue, Wan, Yanping, Liao, Daiqing
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2003
Fag:
Transformation and Oncogenesis
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC229361/
https://ncbi.nlm.nih.gov/pubmed/14557665
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.77.21.11809-11821.2003
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