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E2F1 facilitates DNA break repair by localizing to break sites and enhancing the expression of homologous recombination factors

The human genome is constantly exposed to both endogenous and exogenous stresses, which can lead to errors in DNA replication and the accumulation of DNA mutations, thereby increasing the risk of cancer development. The transcription factor E2F1 is a key regulator of DNA repair. E2F1 also has define...

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Pubblicato in:Exp Mol Med
Autori principali: Choi, Eui-Hwan, Kim, Keun Pil
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2019
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6802646/
https://ncbi.nlm.nih.gov/pubmed/31534120
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s12276-019-0307-2
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