DEK is required for homologous recombination repair of DNA breaks

DEK is a highly conserved chromatin-bound protein whose upregulation across cancer types correlates with genotoxic therapy resistance. Loss of DEK induces genome instability and sensitizes cells to DNA double strand breaks (DSBs), suggesting defects in DNA repair. While these DEK-deficiency phenotyp...

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Veröffentlicht in:Sci Rep
Hauptverfasser: Smith, Eric A., Gole, Boris, Willis, Nicholas A., Soria, Rebeca, Starnes, Linda M., Krumpelbeck, Eric F., Jegga, Anil G., Ali, Abdullah M., Guo, Haihong, Meetei, Amom R., Andreassen, Paul R., Kappes, Ferdinand, Vinnedge, Lisa M. Privette, Daniel, Jeremy A., Scully, Ralph, Wiesmüller, Lisa, Wells, Susanne I.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2017
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5357905/
https://ncbi.nlm.nih.gov/pubmed/28317934
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep44662
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