DEK is required for homologous recombination repair of DNA breaks

DEK is a highly conserved chromatin-bound protein whose upregulation across cancer types correlates with genotoxic therapy resistance. Loss of DEK induces genome instability and sensitizes cells to DNA double strand breaks (DSBs), suggesting defects in DNA repair. While these DEK-deficiency phenotyp...

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Detaylı Bibliyografya
Yayımlandı:Sci Rep
Asıl Yazarlar: Smith, Eric A., Gole, Boris, Willis, Nicholas A., Soria, Rebeca, Starnes, Linda M., Krumpelbeck, Eric F., Jegga, Anil G., Ali, Abdullah M., Guo, Haihong, Meetei, Amom R., Andreassen, Paul R., Kappes, Ferdinand, Vinnedge, Lisa M. Privette, Daniel, Jeremy A., Scully, Ralph, Wiesmüller, Lisa, Wells, Susanne I.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Nature Publishing Group 2017
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5357905/
https://ncbi.nlm.nih.gov/pubmed/28317934
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep44662
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