SPIN90, an adaptor protein, alters the proximity between Rab5 and Gapex5 and facilitates Rab5 activation during EGF endocytosis

During ligand-mediated receptor endocytosis, the small GTPase Rab5 functions in vesicle fusion and trafficking. Rab5 activation is known to require interactions with its guanine nucleotide-exchange factors (GEFs); however, the mechanism regulating Rab5 interactions with GEFs remains unclear. Here, w...

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Détails bibliographiques
Publié dans:Exp Mol Med
Auteurs principaux: Kim, Hwan, Oh, Hyejin, Oh, Young Soo, Bae, Jeomil, Hong, Nan Hyung, Park, Su Jung, Ahn, Suyeon, Lee, Miriam, Rhee, Sangmyung, Lee, Sung Haeng, Jun, Youngsoo, Kim, Sung Hyun, Huh, Yun Hyun, Song, Woo Keun
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group UK 2019
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6802610/
https://ncbi.nlm.nih.gov/pubmed/31358736
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s12276-019-0284-5
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