Xanthine Oxidase Inhibitor Febuxostat Exerts an Anti-Inflammatory Action and Protects against Diabetic Nephropathy Development in KK-Ay Obese Diabetic Mice

Hyperuricemia has been recognized as a risk factor for insulin resistance as well as one of the factors leading to diabetic kidney disease (DKD). Since DKD is the most common cause of end-stage renal disease, we investigated whether febuxostat, a xanthine oxidase (XO) inhibitor, exerts a protective...

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Detalhes bibliográficos
Publicado no:Int J Mol Sci
Main Authors: Mizuno, Yu, Yamamotoya, Takeshi, Nakatsu, Yusuke, Ueda, Koji, Matsunaga, Yasuka, Inoue, Masa-Ki, Sakoda, Hideyuki, Fujishiro, Midori, Ono, Hiraku, Kikuchi, Takako, Takahashi, Masahiro, Morii, Kenichi, Sasaki, Kensuke, Masaki, Takao, Asano, Tomoichiro, Kushiyama, Akifumi
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6801943/
https://ncbi.nlm.nih.gov/pubmed/31546603
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms20194680
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