The Antitumor Effect of Lipophilic Bisphosphonate BPH1222 in Melanoma Models: The Role of the PI3K/Akt Pathway and the Small G Protein Rheb

Malignant melanoma is one of the most metastatic cancer types, and despite recent success with novel treatment strategies, there is still a group of patients who do not respond to any therapies. Earlier, the prenylation inhibitor hydrophilic bisphosphonate zoledronic acid (ZA) was found to inhibit m...

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Vydáno v:Int J Mol Sci
Hlavní autoři: Rittler, Dominika, Baranyi, Marcell, Molnár, Eszter, Garay, Tamás, Jalsovszky, István, Varga, Imre Károly, Hegedűs, Luca, Aigner, Clemens, Tóvári, József, Tímár, József, Hegedűs, Balázs
Médium: Artigo
Jazyk:Inglês
Vydáno: MDPI 2019
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6801414/
https://ncbi.nlm.nih.gov/pubmed/31623406
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms20194917
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