Horizontal Combination of MEK and PI3K/mTOR Inhibition in BRAF Mutant Tumor Cells with or without Concomitant PI3K Pathway Mutations

The RAS/RAF and PI3K/Akt pathways play a key regulatory role in cancer and are often hit by oncogenic mutations. Despite molecular targeting, the long-term success of monotherapy is often hampered by de novo or acquired resistance. In the case of concurrent mutations in both pathways, horizontal com...

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Bibliographic Details
Published in:Int J Mol Sci
Main Authors: Rittler, Dominika, Molnár, Eszter, Baranyi, Marcell, Garay, Tamás, Hegedűs, Luca, Aigner, Clemens, Tóvári, József, Tímár, József, Hegedűs, Balázs
Format: Artigo
Language:Inglês
Published: MDPI 2020
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7589607/
https://ncbi.nlm.nih.gov/pubmed/33081092
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms21207649
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