Allosteric and ATP-Competitive MEK-Inhibition in a Novel Spitzoid Melanoma Model with a RAF- and Phosphorylation-Independent Mutation

SIMPLE SUMMARY: Spitzoid melanoma is a rare tumor type and so far preclinical models for translational research have also been also lacking. We established a cell line from a metastatic spitzoid melanoma that is, according to our knowledge, the first cell model from this tumor type. The cells carrie...

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Bibliographic Details
Published in:Cancers (Basel)
Main Authors: Hegedüs, Luca, Okumus, Özlem, Livingstone, Elisabeth, Baranyi, Marcell, Kovács, Ildikó, Döme, Balázs, Tóvári, József, Bánkfalvi, Ágnes, Schadendorf, Dirk, Aigner, Clemens, Hegedüs, Balázs
Format: Artigo
Language:Inglês
Published: MDPI 2021
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7920251/
https://ncbi.nlm.nih.gov/pubmed/33669371
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cancers13040829
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