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Pan-RAF and MEK vertical inhibition enhances therapeutic response in non-V600 BRAF mutant cells

BACKGROUND: Currently, there are no available targeted therapy options for non-V600 BRAF mutated tumors. The aim of this study was to investigate the effects of RAF and MEK concurrent inhibition on tumor growth, migration, signaling and apoptosis induction in preclinical models of non-V600 BRAF muta...

詳細記述

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書誌詳細
出版年:BMC Cancer
主要な著者: Molnár, Eszter, Rittler, Dominika, Baranyi, Marcell, Grusch, Michael, Berger, Walter, Döme, Balázs, Tóvári, József, Aigner, Clemens, Tímár, József, Garay, Tamás, Hegedűs, Balázs
フォーマット: Artigo
言語:Inglês
出版事項: BioMed Central 2018
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC5941622/
https://ncbi.nlm.nih.gov/pubmed/29739364
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12885-018-4455-x
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