Pan-RAF and MEK vertical inhibition enhances therapeutic response in non-V600 BRAF mutant cells

BACKGROUND: Currently, there are no available targeted therapy options for non-V600 BRAF mutated tumors. The aim of this study was to investigate the effects of RAF and MEK concurrent inhibition on tumor growth, migration, signaling and apoptosis induction in preclinical models of non-V600 BRAF muta...

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Bibliografische gegevens
Gepubliceerd in:BMC Cancer
Hoofdauteurs: Molnár, Eszter, Rittler, Dominika, Baranyi, Marcell, Grusch, Michael, Berger, Walter, Döme, Balázs, Tóvári, József, Aigner, Clemens, Tímár, József, Garay, Tamás, Hegedűs, Balázs
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: BioMed Central 2018
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Research Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5941622/
https://ncbi.nlm.nih.gov/pubmed/29739364
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12885-018-4455-x
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