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Pan-RAF and MEK vertical inhibition enhances therapeutic response in non-V600 BRAF mutant cells
BACKGROUND: Currently, there are no available targeted therapy options for non-V600 BRAF mutated tumors. The aim of this study was to investigate the effects of RAF and MEK concurrent inhibition on tumor growth, migration, signaling and apoptosis induction in preclinical models of non-V600 BRAF muta...
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| Izdano u: | BMC Cancer |
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| Glavni autori: | , , , , , , , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
BioMed Central
2018
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5941622/ https://ncbi.nlm.nih.gov/pubmed/29739364 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12885-018-4455-x |
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