Pan-RAF and MEK vertical inhibition enhances therapeutic response in non-V600 BRAF mutant cells

BACKGROUND: Currently, there are no available targeted therapy options for non-V600 BRAF mutated tumors. The aim of this study was to investigate the effects of RAF and MEK concurrent inhibition on tumor growth, migration, signaling and apoptosis induction in preclinical models of non-V600 BRAF muta...

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Detalhes bibliográficos
Publicado no:BMC Cancer
Main Authors: Molnár, Eszter, Rittler, Dominika, Baranyi, Marcell, Grusch, Michael, Berger, Walter, Döme, Balázs, Tóvári, József, Aigner, Clemens, Tímár, József, Garay, Tamás, Hegedűs, Balázs
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2018
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5941622/
https://ncbi.nlm.nih.gov/pubmed/29739364
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12885-018-4455-x
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