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Withaferin A inhibits expression of ataxia telangiectasia and Rad3-related kinase and enhances sensitivity of human breast cancer cells to cisplatin

Ataxia telangiectasia and Rad3-related (ATR) is a serine/threonine-specific kinase that plays an important role in the maintenance of genomic integrity. In this study, we investigated the role of ATR in cell cycle arrest by withaferin A (WA), a cancer preventative steroidal lactone derived from With...

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Publicat a:Mol Carcinog
Autors principals: Hahm, Eun-Ryeong, Lee, Joomin, Abella, Terric, Singh, Shivendra V.
Format: Artigo
Idioma:Inglês
Publicat: 2019
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6800812/
https://ncbi.nlm.nih.gov/pubmed/31441116
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/mc.23104
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