Early Postnatal Exposure to Isoflurane Disrupts Oligodendrocyte Development and Myelin Formation in the Mouse Hippocampus.

BACKGROUND: Early postnatal exposure to general anesthetics may interfere with brain development. We tested the hypothesis that isoflurane causes a lasting disruption in myelin development via actions on the mammalian target of rapamycin (mTOR) pathway. METHODS: Mice were exposed to 1.5% isoflurane...

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Bibliographic Details
Published in:Anesthesiology
Main Authors: Li, Qun, Mathena, Reilley P., Xu, Jing, Eregha, O’Rukevwe N., Wen, Jieqiong, Mintz, Cyrus D.
Format: Artigo
Language:Inglês
Published: 2019
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6800770/
https://ncbi.nlm.nih.gov/pubmed/31436548
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/ALN.0000000000002904
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