Aspartoacylase deficiency affects early postnatal development of oligodendrocytes and myelination

Canavan disease (CD) is a neurodegenerative disease, caused by a deficiency in the enzyme aspartoacylase (ASPA). This enzyme has been localized to oligodendrocytes; however, it is still undefined how ASPA deficiency affects oligodendrocyte development. In normal mice the pattern of ASPA expression c...

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Hauptverfasser: Mattan, Natalia S., Ghiani, Cristina A., Lloyd, Marcia, Matalon, Reuben, Bok, Dean, Casaccia, Patrizia, de Vellis, Jean
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2010
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2964840/
https://ncbi.nlm.nih.gov/pubmed/20637282
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nbd.2010.07.003
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