Early postnatal exposure to isoflurane causes cognitive deficits and disrupts development of newborn hippocampal neurons via activation of the mTOR pathway

Clinical and preclinical studies indicate that early postnatal exposure to anesthetics can lead to lasting deficits in learning and other cognitive processes. The mechanism underlying this phenomenon has not been clarified and there is no treatment currently available. Recent evidence suggests that...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:PLoS Biol
Main Authors: Kang, Eunchai, Jiang, Danye, Ryu, Yun Kyoung, Lim, Sanghee, Kwak, Minhye, Gray, Christy D., Xu, Michael, Choi, Jun H., Junn, Sue, Kim, Jieun, Xu, Jing, Schaefer, Michele, Johns, Roger A., Song, Hongjun, Ming, Guo-Li, Mintz, C. David
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2017
Teme:
Short Reports
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5500005/
https://ncbi.nlm.nih.gov/pubmed/28683067
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.2001246
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