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DOT1L complex suppresses transcription from enhancer elements and ectopic RNAi in Caenorhabditis elegans

Methylation of histone H3 on lysine 79 (H3K79) by DOT1L is associated with actively transcribed genes. Earlier, we described that DOT-1.1, the Caenorhabditis elegans homolog of mammalian DOT1L, cooperates with the chromatin-binding protein ZFP-1 (AF10 homolog) to negatively modulate transcription of...

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Detalhes bibliográficos
Publicado no:RNA
Main Authors: Esse, Ruben, Gushchanskaia, Ekaterina S., Lord, Avery, Grishok, Alla
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2019
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6800474/
https://ncbi.nlm.nih.gov/pubmed/31300558
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1261/rna.070292.119
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