How internal cavities destabilize a protein

Although many proteins possess a distinct folded structure lying at a minimum in a funneled free energy landscape, thermal energy causes any protein to continuously access lowly populated excited states. The existence of excited states is an integral part of biological function. Although transitions...

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Bibliografiske detaljer
Udgivet i:Proc Natl Acad Sci U S A
Main Authors: Xue, Mengjun, Wakamoto, Takuro, Kejlberg, Camilla, Yoshimura, Yuichi, Nielsen, Tania Aaquist, Risør, Michael Wulff, Sanggaard, Kristian Wejse, Kitahara, Ryo, Mulder, Frans A. A.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2019
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6800337/
https://ncbi.nlm.nih.gov/pubmed/31570587
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1911181116
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