How epigallocatechin gallate binds and assembles oligomeric forms of human alpha-synuclein

The intrinsically disordered human protein α-synuclein (αSN) can self-associate into oligomers and amyloid fibrils. Several lines of evidence suggest that oligomeric αSN is cytotoxic, making it important to devise strategies to either prevent oligomer formation and/or inhibit the ensuing toxicity. (...

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Detaylı Bibliyografya
Yayımlandı:J Biol Chem
Asıl Yazarlar: Andersen, Camilla B., Yoshimura, Yuichi, Nielsen, Janni, Otzen, Daniel E., Mulder, Frans A.A.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society for Biochemistry and Molecular Biology 2021
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC8191297/
https://ncbi.nlm.nih.gov/pubmed/34019875
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jbc.2021.100788
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