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Influence of the Structural Accuracy of Homology Models on Their Applicability to Docking-Based Virtual Screening: the β(2) Adrenergic Receptor as a Case Study

How accurate do structures of the β(2) adrenergic receptor (β(2)AR) need to be to effectively serve as platforms for docking-based virtual screening campaigns? To answer this research question, here we targeted through controlled virtual screening experiments 23 homology models of the β(2)AR endowed...

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Publicat a:J Chem Inf Model
Autors principals: Costanzi, Stefano, Cohen, Austin, Danfora, Abigail, Dolatmoradi, Marjan
Format: Artigo
Idioma:Inglês
Publicat: 2019
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6800073/
https://ncbi.nlm.nih.gov/pubmed/31257873
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jcim.9b00380
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