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On the applicability of GPCR homology models to computer-aided drug discovery: a comparison between in silico and crystal structures of the β(2)-adrenergic receptor
The publication of the crystal structure of the β(2)-adrenergic receptor (β(2)-AR) proved that G protein-coupled receptors (GPCRs) share a structurally conserved rhodopsin-like 7TM core. Here, to probe to which extent realistic GPCR structures can be recreated through modeling, carazolol was docked...
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2008
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| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2443693/ https://ncbi.nlm.nih.gov/pubmed/18442228 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm800044k |
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