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In silico analysis of the binding of agonists and blockers to the β(2)-adrenergic receptor

Activation of G protein-coupled receptors (GPCRs) is a complex phenomenon. Here, we applied Induced Fit docking (IFD) in tandem with linear discriminant analysis (LDA) to generate hypotheses on the conformational changes induced to the β(2)-adrenergic receptor by agonist binding, preliminary to the...

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Hlavní autoři: Vilar, Santiago, Karpiak, Joel, Berk, Barkin, Costanzi, Stefano
Médium: Artigo
Jazyk:Inglês
Vydáno: 2011
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3119336/
https://ncbi.nlm.nih.gov/pubmed/21334234
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmgm.2011.01.005
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